Engineering of a synthetic quadrastable gene network to approach Waddington landscape and cell fate determination

Fuqing Wu1, Ri-Qi Su1,2, Ying-Cheng Lai2,3,4, Xiao Wang1*

1School of Biological and Health Systems Engineering, Arizona State University, Tempe, United States; 2School of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, United States; 3Institute for Complex Systems and Mathematical Biology, King’s College, University of Aberdeen, Aberdeen, United Kingdom; 4Department of Physics, Arizona State University, Tempe, United States