Publications

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Standage-Beier K†, Brookhouser N, Balachandran P, Brafman D∗, and Wang X∗. RNA-Guided Recombinase-Cas9 Fusion Targets Genomic DNA Deletion and Integration. The CRISPR Journal 2019, 4, 209-222PDF
Standage-Beier K†, Tekel SJ†, Brookhouser N†, Schwarz G, Nguyen T, Wang X∗, and Brafman D∗. A transient reporter for editing enrichment (TREE) in human cells. Nucleic Acids Research 2019, 10.1093/nar/gkz713PDF
Menn DJ, Sochor P, Goetz Hanah, Tian XJ∗, and Wang X∗. Intracellular Noise Level Determines Ratio Control Strategy Confined by Speed Accuracy Trade-off. ACS Synthetic Biology 2019, 6,1352-1360PDF
Menn DJ, Wang X. Modeling Gene Networks to Understand Multistability in Stem Cells. 2019, Computational Stem Cell Biology
Menn DJ, Pradhan S, Kiani S, Wang X. Fluorescent Guide RNAs Facilitate Development of Layered Pol II-Driven CRISPR Circuits. ACS Synthetic Biology 2018, 8, 1929-1936PDF
cellsystems_thumbnailWu F, Zhang Q, Wang X. Design of Adjacent Transcriptional Regions to Tune Gene Expression and Facilitate Circuit Construction. Cell Systems 2018, 6(2), 206-215
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quantitativebiology_thumbnail_v3Menn DJ, Su R-Q, Wang X. Control of synthetic gene networks and its applications. Quantitative Biology. 2017, 5(2), 124-135, doi:10.1007/s40484-017-0106-5PDF
Wu F, Su R-Q, Lai Y-C, Wang X. Engineering of a synthetic quadrastable gene network to approach Waddington landscape and cell fate determination. ELife. 2017, 6, e23702, doi:http://dx.doi.org/10.7554/eLife.23702PDF
Standage-Beier K, Wang X. Genome Reprogramming for Synthetic Biology. Frontiers of Chemical Science and Engineering. 2017, doi:10.1007/s11705-017-1618-2PDF
Wang L-Z, Su R-Q, Huang Z-G, Wang X, Wang W-X, Grebogi C and Lai Y-C. A geometrical approach to control and controllability of nonlinear dynamical networks. Nature Communications. 2016,7, doi:10.1038/ncomms11323PDF
Wang L-Z, Wu F, Flores K, Lai Y-C, Wang X. Build to understand: synthetic approaches to biology. Integrative Biology. 2016, 8,
394, doi: 10.1039/c5ib00252d
PDF
Standage-Beier K, Zhang Q, Wang X. Targeted Large-Scale Deletion of Bacterial Genomes Using CRISPR-Nickases. ACS Synthetic Biology. 2015, 4(11), 1217–1225
doi:10.1021/acssynbio. 5b00132
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Wu F,  Wang X. Applications of synthetic gene networks. Science Progress,98(3), 244-252, doi:10.3184/003685015X14368807556 441 PDF
Wu F, Menn DJ,  Wang X. Quorum-Sensing Crosstalk-Driven Synthetic Circuits: From Unimodality to Trimodality. Chemistry & biology,21(12), 1629-1638 doi: 10.1016/j.chembiol.2014.10.008 (2014)PDF
Thumbnail1Faucon PC, Pardee K, Kumar RM, Li H, Loh Y-H, Wang X. Gene Networks of Fully Connected Triads with Complete Auto-Activation Enable Multistability and Stepwise Stochastic TransitionsPLoS ONE, 9(7), e102873. doi:10.1371/journal.pone.0102873 (2014) PDF
Thumbnail16Menn DJ, Wang X. Stochastic and Deterministic Decision in Cell Fate. eLS. (2014)PDF
 Thumbnail2Su R-Q, Lai Y-C, Wang, X. Identifying Chaotic FitzHugh–Nagumo Neurons Using Compressive Sensing. Entropy, 16(7), 3889-3902. (2014)PDF
Thumbnail3Su R-Q, Lai Y-C, Wang X, and Do Y. Uncovering hidden nodes in complex networks in the presence of noise. Sci. Rep. 4. (2014)PDF
Thumbnail4Wu M, Su R-Q, Li X, Ellis T, Lai Y-C, Wang X. Engineering of regulated stochastic cell fate determination. Proceedings of the National Academy of Sciences USA 110:10610-10615 (2013)PDF
Thumbnail5Dari A, Kia B, Wang X, Bulsara A, Ditto W. Noise-aided computation within a synthetic gene network through morphable and robust logic gates. Physical Review E – Statistical, Nonlinear, and Soft Matter Physics 83(4) (2011)PDF
Thumbnail6Dari A, Bulsara A, Ditto W., Wang X. Reprogrammable biological logic gate that exploits noise. IEEE Biomedical Circuits and Systems Conference, BioCAS:337-340 (2011)PDF
Thumbnail7Murphy K, Adams R., Wang X, Balazsi G, Collins J. Tuning and controlling gene expression noise in synthetic gene networks. Nucleic Acids Research 38(8):2712-2726 (2010)PDF
 Thumbnail8Friedland AE*, Lu TK*, Wang X, Shi D, Church GM and Collins JJ. Synthetic Gene Networks That Count. Science 324:1199-1202 (2009) (* equally contributed)PDF
Thumbnail9Ellis T*, Wang X* and Collins JJ. Diversity-based, Model-guided Construction of Synthetic Gene Networks with Predicted Functions. Nature Biotechnology 27: 465-471 (2009). (* equally contributed)PDF
 Thumbnail10Ellis T, Wang X and Collins JJ. Gene Regulation: Hacking the Network on a Sugar High. Molecular Cell 30:1-2 (2008)PDF
Thumbnail11Wang X, Errede B and Elston TC. Mathematical Analysis and Quantification of Fluorescent Proteins as Transcriptional Reporters. Biophysical Journal 94:2017-2026 (2008)PDF
Thumbnail12Guido NJ, Lee P, Wang X, Elston TC and Collins JJ. A Pathway and Genetic Factors Contributing to Elevated Gene Expression Noise in Stationary Phase. Biophysical Journal 93:L55-L57 (2007)PDF
 Thumbnail13Erban R, Frewen T, Wang X, Elston TC, Coifman R, Nadler B and Kevrekidis I. Variable-free Exploration of Stochastic Models: A Gene Regulatory Network Example. Journal of Chemical Physics 126:155103 (2007)PDF
Thumbnail14Wang X, Hao N, Dohlman H and Elston TC. Bistability, Stochasticity, and Oscillations in the Mitogen-Activated Protein Kinase Cascade. Biophysical Journal 90:1961-1978 (2006)PDF
Thumbnail15Guido NJ*, Wang X*, Adalsteinsson D, McMillen D, Hasty J, Cantor CR, Elston TC and Collins JJ. A Bottom-Up Approach to Gene Regulation. Nature 439:856-860 (2006). (* equally contributed)PDF